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PLOS Computational Biology: Exploring the Evolution of Novel Enzyme Functions...
Evolution of…Enzyme Functions w/in Structural…Superfamilies http://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1002403 Most changes involve substrates rather than chemistry develops...
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Structural insights into mis-regulation of protein kinase A in human tumors
Hendrickson cites: Structural insights into mis-regulation of PKA in…tumorshttp://www.pnas.org/content/112/5/1374 SNV stops reg. domain binding #ICSG2015 In other case showed recurring DnaJ–PKA fusion...
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Unraveling determinants of transcription factor binding outside the core...
Segal cites: Determinants of TF binding outside the core binding site http://genome.cshlp.org/content/early/2015/06/05/gr.185033.114.abstract Large-scale measurement of affinity #ICSG2015
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Inferring gene regulatory logic from high-throughput measurements of...
Segal cites: Measurements of 1000s of…designed promoters http://www.nature.com/nbt/journal/v30/n6/full/nbt.2205.html Num. binding sites correlated w/ expr., for 1st few #ICSG2015
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Evolution and Functional Impact of Rare Coding Variation from Deep Sequencing...
Func. Impact of Rare…Variation from Deep Sequencing…Exomes http://www.sciencemag.org/content/337/6090/64.abstract Relation to Protein Structural features (eg a-helices) Science 6 July 2012: Vol. 337...
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